AustralieFrV1, Main, Exploration, bibRecord, 001324

PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study

Identifieur interne : 001324 ( Main/Exploration ); précédent : 001323; suivant : 001325

PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study

Auteurs : Pavel Hamet ; Mounsif Haloui ; François Harvey ; François-Christophe Marois-Blanchet ; Marie-Pierre Sylvestre ; Muhammad-Ramzan Tahir ; Paul H. G. Simon ; Beatriz Sonja Kanzki [Canada] ; John Raelson ; Carole Long ; John Chalmers [Australie] ; Mark Woodward [Australie] ; Michel Marre [France] ; Stephen Harrap [Australie] ; Johanne Tremblay

Source :

Journal of Hypertension [ 0263-6352 ] ; 2017.

RBID : PMC:5377997

Descripteurs français

English descriptors

KwdEn :
- Age of Onset, Aged, Albuminuria (ethnology), Albuminuria (genetics), Diabetes Mellitus, Type 2 (ethnology), Diabetes Mellitus, Type 2 (genetics), Diabetic Nephropathies (ethnology), Diabetic Nephropathies (genetics), Ethnic Groups (genetics), European Continental Ancestry Group (genetics), Female, Genome-Wide Association Study, Genotype, Homeodomain Proteins (genetics), Humans, Hypertension (ethnology), Male, Middle Aged, Polymorphism, Single Nucleotide, Tumor Suppressor Proteins (genetics).
MESH :
- chemical , genetics : Homeodomain Proteins, Tumor Suppressor Proteins.
- ethnology : Albuminuria, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Hypertension.
- genetics : Albuminuria, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Ethnic Groups, European Continental Ancestry Group.
- Age of Onset, Aged, Female, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.

Abstract

Background:

The prevalence of diabetic nephropathy varies according to ethnicity. Environmental as well as genetic factors contribute to the heterogeneity in the presentation of diabetic nephropathy. Our objective was to evaluate this heterogeneity within the Caucasian population.

Methods:

The geo-ethnic origin of the 3409 genotyped Caucasian type 2 diabetes (T2D) patients of Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation was determined using principal component analysis. Genome-wide association studies analyses of age of onset of T2D were performed for geo-ethnic groups separately and combined.

Results:

The first principal component separated the Caucasian study participants into Slavic and Celtic ethnic origins. Age of onset of diabetes was significantly lower in Slavic patients (P = 7.3 × 10⁻²⁰), whereas the prevalence of hypertension (P = 4.9 × 10⁻³¹) and albuminuria (5.1 × 10⁻⁹) were significantly higher. Age of onset of T2D and albuminuria appear to have an important genetic component as the values of these traits were also different between Slavic and Celtic individuals living in the same countries. Common and geo-ethnic-specific loci were found to be associated to age of onset of diabetes. Among the latter, the PROX1/PROX1-AS1 genes (rs340841) had the highest impact. Single-nucleotide polymorphism rs340841 CC genotype was associated with a 4.4 year earlier onset of T2D in Slavic patients living or not in countries with predominant Slavic populations.

Conclusion:

These results reveal the presence of distinct genetic architectures between Caucasian ethnic groups that likely have clinical relevance, among them PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377997

DOI: 10.1097/HJH.0000000000001241
PubMed: 28060188
PubMed Central: 5377997

Affiliations:

Le document en format XML

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 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study</title>
<author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name>
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<author><name sortKey="Marois Blanchet, Francois Christophe" sort="Marois Blanchet, Francois Christophe" uniqKey="Marois Blanchet F" first="François-Christophe" last="Marois-Blanchet">François-Christophe Marois-Blanchet</name>
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<author><name sortKey="Sylvestre, Marie Pierre" sort="Sylvestre, Marie Pierre" uniqKey="Sylvestre M" first="Marie-Pierre" last="Sylvestre">Marie-Pierre Sylvestre</name>
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<author><name sortKey="Tahir, Muhammad Ramzan" sort="Tahir, Muhammad Ramzan" uniqKey="Tahir M" first="Muhammad-Ramzan" last="Tahir">Muhammad-Ramzan Tahir</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>PROX1</italic>
 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study</title>
<author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name>
<affiliation><nlm:aff id="aff1">Department of Medicine, Gene Medicine Services</nlm:aff>
<wicri:noCountry code="subfield">Gene Medicine Services</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff2">Department of Medicine</nlm:aff>
</affiliation>
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<author><name sortKey="Haloui, Mounsif" sort="Haloui, Mounsif" uniqKey="Haloui M" first="Mounsif" last="Haloui">Mounsif Haloui</name>
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</affiliation>
</author>
<author><name sortKey="Harvey, Francois" sort="Harvey, Francois" uniqKey="Harvey F" first="François" last="Harvey">François Harvey</name>
<affiliation><nlm:aff id="aff2">Department of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Marois Blanchet, Francois Christophe" sort="Marois Blanchet, Francois Christophe" uniqKey="Marois Blanchet F" first="François-Christophe" last="Marois-Blanchet">François-Christophe Marois-Blanchet</name>
<affiliation><nlm:aff id="aff2">Department of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sylvestre, Marie Pierre" sort="Sylvestre, Marie Pierre" uniqKey="Sylvestre M" first="Marie-Pierre" last="Sylvestre">Marie-Pierre Sylvestre</name>
<affiliation><nlm:aff id="aff3">Department of Social and Preventive Medicine, Université de Montréal, CRCHUM</nlm:aff>
<wicri:noCountry code="subfield">CRCHUM</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tahir, Muhammad Ramzan" sort="Tahir, Muhammad Ramzan" uniqKey="Tahir M" first="Muhammad-Ramzan" last="Tahir">Muhammad-Ramzan Tahir</name>
<affiliation><nlm:aff id="aff2">Department of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simon, Paul H G" sort="Simon, Paul H G" uniqKey="Simon P" first="Paul H. G." last="Simon">Paul H. G. Simon</name>
<affiliation><nlm:aff id="aff2">Department of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kanzki, Beatriz Sonja" sort="Kanzki, Beatriz Sonja" uniqKey="Kanzki B" first="Beatriz Sonja" last="Kanzki">Beatriz Sonja Kanzki</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Software Engineering and the Information Technology, École de Technologie Supérieure, Montreal, Quebec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Software Engineering and the Information Technology, École de Technologie Supérieure, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Raelson, John" sort="Raelson, John" uniqKey="Raelson J" first="John" last="Raelson">John Raelson</name>
<affiliation><nlm:aff id="aff2">Department of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Long, Carole" sort="Long, Carole" uniqKey="Long C" first="Carole" last="Long">Carole Long</name>
<affiliation><nlm:aff id="aff2">Department of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
<affiliation wicri:level="4"><nlm:aff id="aff5">The George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
<affiliation wicri:level="4"><nlm:aff id="aff5">The George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name>
<affiliation wicri:level="3"><nlm:aff id="aff6">Hôpital Bichat, Claude Bernard, Université Paris 7, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Bichat, Claude Bernard, Université Paris 7, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name>
<affiliation wicri:level="4"><nlm:aff id="aff7">Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tremblay, Johanne" sort="Tremblay, Johanne" uniqKey="Tremblay J" first="Johanne" last="Tremblay">Johanne Tremblay</name>
<affiliation><nlm:aff id="aff1">Department of Medicine, Gene Medicine Services</nlm:aff>
<wicri:noCountry code="subfield">Gene Medicine Services</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff2">Department of Medicine</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Hypertension</title>
<idno type="ISSN">0263-6352</idno>
<idno type="eISSN">1473-5598</idno>
<imprint><date when="2017">2017</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term>
<term>Aged</term>
<term>Albuminuria (ethnology)</term>
<term>Albuminuria (genetics)</term>
<term>Diabetes Mellitus, Type 2 (ethnology)</term>
<term>Diabetes Mellitus, Type 2 (genetics)</term>
<term>Diabetic Nephropathies (ethnology)</term>
<term>Diabetic Nephropathies (genetics)</term>
<term>Ethnic Groups (genetics)</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Homeodomain Proteins (genetics)</term>
<term>Humans</term>
<term>Hypertension (ethnology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Tumor Suppressor Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Albuminurie (ethnologie)</term>
<term>Albuminurie (génétique)</term>
<term>Diabète de type 2 (ethnologie)</term>
<term>Diabète de type 2 (génétique)</term>
<term>Femelle</term>
<term>Groupes ethniques (génétique)</term>
<term>Génotype</term>
<term>Humains</term>
<term>Hypertension artérielle (ethnologie)</term>
<term>Mâle</term>
<term>Néphropathies diabétiques (ethnologie)</term>
<term>Néphropathies diabétiques (génétique)</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine européenne (génétique)</term>
<term>Protéines suppresseurs de tumeurs (génétique)</term>
<term>Protéines à homéodomaine (génétique)</term>
<term>Sujet âgé</term>
<term>Âge de début</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Homeodomain Proteins</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Albuminurie</term>
<term>Diabète de type 2</term>
<term>Hypertension artérielle</term>
<term>Néphropathies diabétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Albuminuria</term>
<term>Diabetes Mellitus, Type 2</term>
<term>Diabetic Nephropathies</term>
<term>Hypertension</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Albuminuria</term>
<term>Diabetes Mellitus, Type 2</term>
<term>Diabetic Nephropathies</term>
<term>Ethnic Groups</term>
<term>European Continental Ancestry Group</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Albuminurie</term>
<term>Diabète de type 2</term>
<term>Groupes ethniques</term>
<term>Néphropathies diabétiques</term>
<term>Population d'origine européenne</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Protéines à homéodomaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term>
<term>Aged</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Sujet âgé</term>
<term>Âge de début</term>
<term>Étude d'association pangénomique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec sec-type="background"><title>Background:</title>
<p>The prevalence of diabetic nephropathy varies according to ethnicity. Environmental as well as genetic factors contribute to the heterogeneity in the presentation of diabetic nephropathy. Our objective was to evaluate this heterogeneity within the Caucasian population.</p>
</sec>
<sec sec-type="methods"><title>Methods:</title>
<p>The geo-ethnic origin of the 3409 genotyped Caucasian type 2 diabetes (T2D) patients of Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation was determined using principal component analysis. Genome-wide association studies analyses of age of onset of T2D were performed for geo-ethnic groups separately and combined.</p>
</sec>
<sec sec-type="results"><title>Results:</title>
<p>The first principal component separated the Caucasian study participants into Slavic and Celtic ethnic origins. Age of onset of diabetes was significantly lower in Slavic patients (<italic>P</italic>
 = 7.3 × 10<sup>−20</sup>
), whereas the prevalence of hypertension (<italic>P</italic>
 = 4.9 × 10<sup>−31</sup>
) and albuminuria (5.1 × 10<sup>−9</sup>
) were significantly higher. Age of onset of T2D and albuminuria appear to have an important genetic component as the values of these traits were also different between Slavic and Celtic individuals living in the same countries. Common and geo-ethnic-specific loci were found to be associated to age of onset of diabetes. Among the latter, the <italic>PROX1/PROX1-AS1</italic>
 genes (rs340841) had the highest impact. Single-nucleotide polymorphism rs340841 CC genotype was associated with a 4.4 year earlier onset of T2D in Slavic patients living or not in countries with predominant Slavic populations.</p>
</sec>
<sec sec-type="conclusion"><title>Conclusion:</title>
<p>These results reveal the presence of distinct genetic architectures between Caucasian ethnic groups that likely have clinical relevance, among them <italic>PROX1</italic>
 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Groop, Ph" uniqKey="Groop P">PH Groop</name>
</author>
<author><name sortKey="Thomas, Mc" uniqKey="Thomas M">MC Thomas</name>
</author>
<author><name sortKey="Moran, Jl" uniqKey="Moran J">JL Moran</name>
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<biblStruct><analytic><author><name sortKey="Dupuis, J" uniqKey="Dupuis J">J Dupuis</name>
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<author><name sortKey="Langenberg, C" uniqKey="Langenberg C">C Langenberg</name>
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<author><name sortKey="Prokopenko, I" uniqKey="Prokopenko I">I Prokopenko</name>
</author>
<author><name sortKey="Saxena, R" uniqKey="Saxena R">R Saxena</name>
</author>
<author><name sortKey="Soranzo, N" uniqKey="Soranzo N">N Soranzo</name>
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<author><name sortKey="Jackson, Au" uniqKey="Jackson A">AU Jackson</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Florez, Jc" uniqKey="Florez J">JC Florez</name>
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<author><name sortKey="Jablonski, Ka" uniqKey="Jablonski K">KA Jablonski</name>
</author>
<author><name sortKey="Mcateer, Jb" uniqKey="Mcateer J">JB McAteer</name>
</author>
<author><name sortKey="Franks, Pw" uniqKey="Franks P">PW Franks</name>
</author>
<author><name sortKey="Mason, Cc" uniqKey="Mason C">CC Mason</name>
</author>
<author><name sortKey="Mather, K" uniqKey="Mather K">K Mather</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gong, Y" uniqKey="Gong Y">Y Gong</name>
</author>
<author><name sortKey="Mcdonough, Cw" uniqKey="Mcdonough C">CW McDonough</name>
</author>
<author><name sortKey="Beitelshees, Al" uniqKey="Beitelshees A">AL Beitelshees</name>
</author>
<author><name sortKey="Karnes, Jh" uniqKey="Karnes J">JH Karnes</name>
</author>
<author><name sortKey="O Onnell, Jr" uniqKey="O Onnell J">JR O’Connell</name>
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<author><name sortKey="Turner, St" uniqKey="Turner S">ST Turner</name>
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</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Melbourne</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Melbourne</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Haloui, Mounsif" sort="Haloui, Mounsif" uniqKey="Haloui M" first="Mounsif" last="Haloui">Mounsif Haloui</name>
<name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name>
<name sortKey="Harvey, Francois" sort="Harvey, Francois" uniqKey="Harvey F" first="François" last="Harvey">François Harvey</name>
<name sortKey="Long, Carole" sort="Long, Carole" uniqKey="Long C" first="Carole" last="Long">Carole Long</name>
<name sortKey="Marois Blanchet, Francois Christophe" sort="Marois Blanchet, Francois Christophe" uniqKey="Marois Blanchet F" first="François-Christophe" last="Marois-Blanchet">François-Christophe Marois-Blanchet</name>
<name sortKey="Raelson, John" sort="Raelson, John" uniqKey="Raelson J" first="John" last="Raelson">John Raelson</name>
<name sortKey="Simon, Paul H G" sort="Simon, Paul H G" uniqKey="Simon P" first="Paul H. G." last="Simon">Paul H. G. Simon</name>
<name sortKey="Sylvestre, Marie Pierre" sort="Sylvestre, Marie Pierre" uniqKey="Sylvestre M" first="Marie-Pierre" last="Sylvestre">Marie-Pierre Sylvestre</name>
<name sortKey="Tahir, Muhammad Ramzan" sort="Tahir, Muhammad Ramzan" uniqKey="Tahir M" first="Muhammad-Ramzan" last="Tahir">Muhammad-Ramzan Tahir</name>
<name sortKey="Tremblay, Johanne" sort="Tremblay, Johanne" uniqKey="Tremblay J" first="Johanne" last="Tremblay">Johanne Tremblay</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Kanzki, Beatriz Sonja" sort="Kanzki, Beatriz Sonja" uniqKey="Kanzki B" first="Beatriz Sonja" last="Kanzki">Beatriz Sonja Kanzki</name>
</noRegion>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
</region>
<name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name>
<name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name>
</region>
</country>
</tree>
</affiliations>
</record>

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   |texte=   PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study
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Serveur d'exploration sur les relations entre la France et l'Australie

PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study

PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study

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	Serveur d'exploration sur les relations entre la France et l'Australie
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